I've used Norton Ghost before, but switched to True Image almost 4 years ago and never looked back. True Image has a slew of enterprise and end-user features and the interface is both easy to use and simple to understand. I can schedule backups over the network to my dedicated file server or to local machines, and even restore from the network drives!
Room for Improvement:
I can't think of a single one. Maybe it would be better if it was a bit cheaper, but good software is worth every penny.
I exclusively use Acronis True Image for my Windows backup needs, both in the enterprise and at home. I haven't found a better solution that allows me to interact with a server and schedule automated backups over the network.