We no longer worry about viruses like Cryptolocker or Cryptowall. If an infection happens, and it has, and will happen again, we don't experience data loss. The most time we spend is identifying the source of the infection. Servers are backed up with CrashPlan and users data is backed up with CrashPlan. We just clean the infection, restore the data and we are done.
Minimal to no data loss, and a lot of time saved as well as user peace of mind.
At first, but we got excellent assistance from top tier support at Code42 and all issues we resolved quickly.
It is not cheap, but when you can restore thousands of hours of work without issue, it does not matter so much.
CrashPlan is one of the top three software implementations I have ever been involved with in 15 years. It makes my job easier. It makes the users jobs easier. I have seen users almost break down and cry tears of joy because we were able to restore critical documentation with years of research so quickly. It makes us in IT support look good.