Our primary use case of Nakivo is to backup a three-way vSphere cluster hosting approximately 50 virtual machines.
We changed backup solutions because our previous one became so top-heavy and cumbersome to use.
We are a large site and use Nakivo to back up to disc between buildings in a limited time window. It then moves backup sets to the cloud as required.
We also use the replication feature to snapshot some of our most critical VMs to a backup server, which could be used if we lost our main datacenter.