A large health care provider was about to start a research project in personalized genomic medicine. That project needed not only considerable computing power to analyse the data gathered, storage was a primary concern. The solution needed to be able to scale into petabytes seamlessly while also scaling in performance. Monetary estaints prohibeted the use of classic storage silos such as EMC Isilon.
Clear communication to stakeholders up to and including C-level executives is paramount to such projects. Involving them as early as possible and even insisting on meeting with them is what I will do more frequently in future projects.